The breakthrough of the century, no more fighting with Logitech Profiler! If you have Steam, you can add MTM2 as a game in the Library, then enable "Steam Input" in the Settings menu for the game in Steam. Then, right click the game, choose Manage -> Controller Layout, and select "Controller". Load up the game, choose "Joystick/Wheel" for controls and enable Throttle Control. You should then be able to use a standard, modern Xbox style controller with the game and the triggers as throttle and brake. An actual game changer in my view - makes it way more enjoyable.
This clip from LinusTechTips explains it visually:
https://youtu.be/dzkULjGtIdk?t=465